殺手細胞免疫球蛋白樣受體(killer cell immunoglobulin-like receptors or KIRs):這些基因具有高度多態性,這意味著它們有許多變異,並影響 NK 細胞活性。研究發現特定的 KIR 變異是危險因子—KIR2DL5B(−)/KIR2DS3(+)/KIR2DS5(−)/KIR2DS4del(+):
風險基因:KIR2DS3 和 KIR2DS4del
保護基因:KIR2DL5B 和 KIR2DS5
細胞特異性表達數量性狀位點(NK cell-specific expression quantitative trait loci or eQTLs):這些是影響對 NK 細胞功能重要的基因表現水平的 DNA 區域。該研究確定了兩個 eQTL 為潛在風險因素:
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